Studiene fant at i de fleste tilfeller var de høyere dosene mindre effektive enn 1 mg-dosen og hadde mer detrimental bivirkninger. Maksimal anbefalt dose er four mg for every dag.Informer pasienter og omsorgspersoner om at potensielt dødelige additiveffekter kan oppstå hvis Klonopin brukes sammen med opioider og ikke bruker slike legemidler samt

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